|
T8239 |
Cromoglicic acid
|
|
Others
|
|
Cromoglicic acid prevents the release of inflammatory chemicals such as histamine from mast cells. |
|
T0211 |
Azelastine
|
Azelastina,Astelin,Azelastinum |
SARS-CoV
,
Histamine Receptor
|
|
|
|
T3979 |
Emedastine
|
LY188695,Emadine |
Histamine Receptor
|
|
Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its... |
|
T21404 |
Fluticasone furoate
|
Veramyst,Allermist,Avamys,Fluticasone furoate |
Glucocorticoid Receptor
|
|
Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure... |
|
T0118 |
Mizolastine
|
SL 850324 |
Histamine Receptor
|
|
Mizolastine (SL 850324) (IC50= 47 nM) is a histamine H1-receptor antagonist.It is used in the treatment of allergic reactions such as hay fever (seasonal allergic rhinitis), hives. |
|
T6242 |
Rupatadine Fumarate
|
Rinialer,Rupafin,Alergoliber |
PAFR
,
Autophagy
,
Histamine Receptor
|
|
Rupatadine Fumarate (Rinialer) (UR-12592 Fumarate) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM. |
|
T0059 |
Diphenylpyraline hydrochloride
|
4-Diphenylmethoxy-1-methylpiperidine hydrochloride |
Histamine Receptor
|
|
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) is used in the treatment of Parkinsonism.It is a first-generation antihistamine with anticholinergic effects, functions as a dopamine re... |
|
T3185 |
R112
|
(E)-Elafibranor |
Syk
|
|
R112 ((E)-Elafibranor) is an ATP-competitive inhibitor of Syk kinase. |
|
T1030 |
Triprolidine hydrochloride monohydrate
|
Triprolidine hydrochloride |
Histamine Receptor
|
|
Triprolidine hydrochloride monohydrate is a histamine H1 antagonist used in allergic rhinitis, asthma. |
|
T0211L |
Azelastine hydrochloride
|
Optivar,Azelastine HCl,Allergodil,Astelin |
SARS-CoV
,
Histamine Receptor
|
|
Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity. |
|
T1269 |
Tripelennamine hydrochloride
|
Pyribenzamine hydrochloride,Tripelennamine HCl,Pyribenzamine HCl |
Histamine Receptor
|
|
Tripelennamine hydrochloride (Pyribenzamine hydrochloride) is a histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. |
|
T2335 |
Ebastine
|
Ebastel,LAS-W 090,Ebastin,Kestine,RP64305 |
Histamine Receptor
|
|
Ebastine (Kestine) (trade names Evastin, Kestine, Ebastel, Aleva) is a non-sedating H1 antihistamine. It does not penetrate the blood-brain barrier and thus allows an effective block of the H1 receptor in peripheral tiss... |
|
T0188 |
Fluticasone (propionate)
|
CCI-187881,Fluticasone propionate |
Glucocorticoid Receptor
,
Virus Protease
,
Estrogen/progestogen Receptor
,
Phospholipase
,
Endogenous Metabolite
|
|
Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist. |
|
T0205 |
Brompheniramine maleate
|
Dimotane,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane |
5-HT Receptor
,
Histamine Receptor
|
|
Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors. |
|
T0089 |
Cetirizine dihydrochloride
|
P071,UCB P071,Cetirizine DiHCl |
Histamine Receptor
|
|
Cetirizine dihydrochloride (UCB P071) is an effective second-generation histamine H1 antagonist that is potent in the therapy of allergic rhinitis, confirmed urticaria, and pollen-induced asthma. Unlike other conventiona... |
|
T6660 |
SB-705498
|
|
TRP/TRPV Channel
|
|
SB705498 is a TRPV1 antagonist for hTRPV1. SB-705498 has been investigated for the treatment of Rhinitis, Chronic Cough, and Non-allergic Rhinitis. |
|
T1553 |
Chlorpheniramine maleate
|
NCI-C55265,Chlorphenamine maleate |
Histamine Receptor
|
|
Chlorpheniramine maleate (NCI-C55265) is a histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. |
|
T1470 |
Fexofenadine hydrochloride
|
Terfenidine carboxylate hydrochloride,MDL-16455 hydrochloride,Telfast,Fexofenadine HCl,Allegra,MDL 16455A |
Histamine Receptor
|
|
Fexofenadine hydrochloride (Terfenidine carboxylate hydrochloride) is a second generation antihistamine that is used for the treatment of allergic rhinitis, angioedema and chronic urticaria. |
|
T77426 |
Pascolizumab
|
SB-240683 |
IL Receptor
|
|
Pascolizumab (SB-240683) is a humanized monoclonal antibody against IL-4. Pascolizumab has asthmatic effects and can be used to study allergic rhinitis. |
|
T1531 |
Mometasone furoate
|
Sch32088 |
Glucocorticoid Receptor
|
|
Mometasone furoate (Sch32088) is a pregnadienediol derivative ANTI-ALLERGIC AGENT and ANTI-INFLAMMATORY AGENT that is used in the management of ASTHMA and ALLERGIC RHINITIS. It is also used as a topical treatment for ski... |
|
T2270 |
Trans-Tranilast
|
Tranilast trans- |
RAAS
|
|
Trans-Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. It was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993.... |
|
T2392 |
Nafamostat mesylate
|
FUT-175 |
Apoptosis
,
Serine/threonin kinase
,
SARS-CoV
,
Serine Protease
|
|
Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis. |
|
T2396 |
Ramatroban
|
BAY u3405 |
GPR
,
Prostaglandin Receptor
,
PPAR
|
|
Ramatroban (BAY u3405) (BAY u3405) is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. It has been used in trials studying the treatment of Asthma. |
|
T1097 |
Loratadine
|
SCH 29851,Loratidine |
Influenza Virus
,
Histamine Receptor
|
|
Loratadine (SCH 29851) is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central ne... |
|
T22354 |
Levocetirizine Dihydrochloride
|
Xyzal Dihydrochloride,(-)-Cetirizine Dihydrochloride |
Histamine Receptor
|
|
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydro... |
|
T1278 |
Astemizole
|
Laridal,Histaminos,Paralergin |
Potassium Channel
,
Histamine Receptor
|
|
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re... |
|
T4563 |
Thonzylamine
|
neohetramine |
Histamine Receptor
|
|
Thonzylamine (neohetramine) is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhin... |
|
T29951 |
Ambicromil
|
|
|
|
Ambicromil is used for allergic rhinitis. |
|
T0785L |
Dexchlorpheniramine free base
|
Polaramine,Dexchlorpheniramine Maleate,Mylaramine |
|
|
Dexchlorpheniramine Maleate, a histamine receptor antagonist, is used to treat urticaria, allergic rhinitis, allergic conjunctivitis and pruritus. |
|
T21112 |
Triprolidine hydrochloride
|
295 C 51,Pro-Entra,Entra,Actidilat,Triprolidine hydrochloride anhydrous,Actidil,Pro-Actidil |
|
|
Triprolidine hydrochloride anhydrous, a Histamine H1 antagonist, is used in asthma, allergic rhinitis, and urticaria. |
|
T27556 |
HSR-609
|
HSR609,FY609,FY-609,FY 609 |
|
|
HSR-609, a histamine H1 receptor antagonist, is used potentially for the treatment of allergic rhinitis. |
|
T27445 |
GSK-1004723
|
GSK 1004723 |
|
|
GSK-1004723 is a novel antagonist of histamine H(1) and H(3) receptor. It represents a potential novel therapy for allergic rhinitis. |
|
T10437 |
AZD8848
|
|
TLR
|
|
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis. |
|
T21247 |
Carbinoxamine
|
Allergefon,(+-)-Carbinoxamine,Paracarbinoxamine |
|
|
Carbinoxamine, an anticholinergic and antihistamine agent, is used for hay fever, angioedema, vasomotor rhinitis, mild urticaria, dermatographism and allergic conjunctivitis. It is a histamine antagonist, specifically an... |
|
T69737 |
SCH-79687
|
|
|
|
SCH-79687 is a histamine antagonist selective for the H3 subtype. This H3 antagonist may play a role in allergic rhinitis. |
|
T16476 |
PF-03654746
|
|
Histamine Receptor
|
|
PF-03654746 is a selective antagonist of the histamine H3 receptor. PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer's disease. PF-03654746 can be used in studies about the treatment of ... |
|
T37386 |
Dihydro Montelukast
|
|
|
|
Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing ... |
|
T73972 |
Fexofenadine Impurity F
|
|
|
|
Fexofenadine Impurity F, an impurity present in Fexofenadine, is characterized by its role in the pharmacological profile of this drug. As a H1R antagonist, Fexofenadine serves as an anti-allergic agent, effectively empl... |
|
T68280 |
Adriforant
|
|
|
|
Adriforant, also known as ZPL-3893787, PF-3893787 and ZPL-389, is a novel histamine H4 receptor antagonist. Adriforant shows an excellent in vitro profile that warrants their further investigation in relevant models of ... |
|
T60514 |
Triprolidine
|
|
|
|
Triprolidine is an orally active antagonist of H1R. Triprolidine has spinal cord motor and sensory block effects. Triprolidine can be used in allergic rhinitis research[1] [2] [3]. |
|
T62669 |
Tripelennamine citrate
|
|
|
|
Tripelennamine citrate is an ethylenediamine derivative and is a potent histamine H1 receptor antagonist. tripelennamine citrate reduces histamine-induced allergic reactions in the body. tripelennamine citrate can be use... |
|
T74646 |
PM-81I
|
|
|
|
PM-81I, a potent STAT6 inhibitor targeting the SH2 structural domain, effectively reduces STAT6 phosphorylation levels. It is applicable in the research of allergic lung disease, allergic rhinitis, chronic obstructive pu... |
|
T73129 |
STAT6-IN-1
|
|
|
|
STAT6-IN-1, a STAT6 inhibitor, exhibits high affinity for the SH2 domain of STAT6 (IC 50 = 0.028 µM), making it suitable for research on allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease, or... |
|
T60392 |
Tripelennamine
|
|
|
|
Tripelennamine, an ethylenediamine derivative, acts as a potent histamine H1-receptor antagonist, effectively reducing the organism's allergic response to histamine. It is utilized in researching conditions such as rhini... |
|
T26770 |
Bencycloquidium Bromide
|
BCQB |
|
|
Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in C... |
|
T69918 |
Adriforant tartrate hydrate
|
|
|
|
Adriforant tartrate hydrate, also known as ZPL-3893787 tartrate hydrate, PF-3893787 tartrate hydrate and ZPL-389 tartrate hydrate, is a novel histamine H4 receptor antagonist. Adriforant tartrate hydrate shows an excelle... |
|
T61213 |
PF-03654764
|
|
Histamine Receptor
|
|
PF-03654764 is an orally active, potent, and selective histamine H3 receptor antagonist that inhibits human H3 and rat H3 with Ki values of 1.2 nM and 7.9 nM, respectively.PF-03654764 is often co-administered with Fexofe... |
|
T38350 |
TAS 205
|
|
|
|
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS ... |
|
T60843 |
Brompheniramine
|
|
|
|
Brompheniramine ((±)-Brompheniramine) is a potent and orally active alkylamine class antihistamine. Brompheniramine is a selective antagonist of histamine H1 receptor (Kd = 6.06 nM). Brompheniramine can be used in the re... |
|
T74583 |
Desmethylazelastine
|
|
|
|
Desmethylazelastine, the primary active metabolite of Azelastine, undergoes oxidative metabolism via the cytochrome P450 enzyme system, exhibits a 97% protein binding rate, and has an elimination half-life of 54 hours. A... |
